Radiation Protocol List

ACNS0232: Radiotherapy Alone vs. Chemotherapy Followed by Response-based Radiotherapy for Newly Diagnosed Primary CNS Germinoma

Physician Summary: ≥ age 3 and ≤ age 30, Newly Dx: XRT vs Carboplatin + Etoposide f/b response based XRT + Chemo

B-39: A Randomized Phase III Study of Conventional Whole Breast Irradiation (WBI) Versus Partial Breast Irradiation (PBI) for Women with Stage 0, I, or II Breast Cancer (St. Mary's & MMC Only)

Physician Summary: <age 50 if stage 0; >age 50 for Stage I & II if Node+ and/or ER-/PR-: Conventional Whole Breast Irradiation (WBI) vs. Partial Breast Irradiation (PBI)

80101: A Phase III Intergroup Trial of Adjuvant Chemoradiation After Resection of Gastric or Gastroesophageal Adenocarcinoma

Physician Summary: S/P Resection: 5FU/LV/XRT vs. ECF/XRT (Ancillary 60201 Suggested)

R-04: A Clinical Trial Comparing Preoperative Radiation Therapy and Capecitabine with or without Oxaliplatin with Preoperative Radiation Therapy and Continuous Intravenous Infusion of 5-Flourouracil with or without Oxaliplatin in the Treatment of Patients with Operable Carcinoma of the Rectum

Physician Summary: Neoadjuvant; Stage II/III; complete colonoscopic exam required: CI 5FU + XRT +/- Oxaliplatin vs Capecitabine + XRT +/- Oxaliplatin

RTOG 0615: (Saint Mary's Only) A Phase II Study of Concurrent Chemoradiotherapy Using Three-Dimensional Conformal Radiotherapy (3D-CT) or Intensity-Modulated Radiation Therapy (IMRT) + Bevacizumab (BV) for Locally or Regionally Advanced Nasopharyngeal Cancer

Physician Summary: (Saint Mary’s Only) WHO I-IIb/III, Stage IIb/IVB, Incisional bx only: RT + Cisplatin + Bevacizumab f/b 5-FU + Cisplatin + Bevacizumab

0522: A Randomized Phase III Trial of Concurrent Accelerated Radiation and Cisplatin vs. Concurrent Accelerated Radiation, Cisplatin, and Cetuximab (C225) [Followed by Surgery for Selected Patients] For Stage III and IV Head and Neck Carcinomas

Physician Summary: (St. Mary’s Only) Stage III – IV: Accelerated Radiation + Cisplatin vs. Accelerated Radiation, Cisplatin + Cetuximab

0618: A Phase II Trial of Stereotactic Body Radiation Therapy (SBRT) in the
Treatment of Patients with Operable Stage I/II Non-Small Cell Lung Cancer

Physician Summary: (St. Mary’s Only) > age 18; Operable Stage I/II: Stereotactic Body Radiation

0617: A Randomized Phase IIII Comparison Of Standard- Dose (60 Gy) Versus High-Dose (74 Gy) Conformal Radiotherapy With Concurrent And Consolidation Carboplatin/Paclitaxel +/- Cetuximab (IND #103444) In Patients With Stage IIIA/IIIB Non-Small Cell Lung Cancer

Physician Summary: Saint Mary's Health Care Only:  ≥ age 18, Newly Dx, unresectable Stage IIIA/IIIB: Standard vs High-dose conformal RT with Concurrent and Consolidation Carboplatin/Paclitaxel

RTOG 0438: (Temp Closed) Phase I Trial of Highly Conformal Radiation Therapy For Patients With Liver Metastases

Physician Summary: ≥ age 18; Stage IV w/Liver Mets; May have Prior Liver Resection or Chemo: Highly Conformal XRT

ARST0332: Risk-Based Treatment for Pediatric Non-Rhabdomyosarcoma Soft Tissue Sarcomas (NRSTS)

Physician Summary: < age 30, Surgery vs Surgery + XRT vs Surgery + Chemo + XRT/Surgery vs Chemo + XRT + Surgery + Chemo + XRT/Surgery (Chemo = Ifosfomide + Doxirubicin)