Radiation Protocol List

COG-ACNS0332: Efficacy of Carboplatin Administered Concomitantly With Radiation and Isotretinoin as a Pro-Apoptotic Agent in Other Than Average Risk Medulloblastoma/PNET Patients

Physician Summary: > Age 21; Newly Dx: RT+ Vincristine +/- Carboplatin f/b Maint +/- Continuous Isotretinoin

N0577: Phase III Intergroup Study of Radiotherapy versus Temozolomide alone versus Radiotherapy with Concomitant and Adjuvant Temozolomide for Patients with 1p/19q Codeleted Anaplastic Glioma

Physician Summary: > Age 18; Staging: Co-deleted 1p/19q Anaplastic Glioma; Treatment: RT vs Temozolomide alone vs RT with concomitant & Adjuvant Temozolomide.

NCCTG N057K: Phase I/II Evaluation of Everolimus (RAD001), Radiation and Temozolomide (TMZ) Followed by Adjuvant Temozolomide and Everolimus in Newly Diagnosed Glioblastoma

Physician Summary:  > Age 18; Grade IV Astrocytoma (GBM); Treatment: Everolimus + RT + Temozolomide f/b Everolimus + Temozolomide f/b Everolimus

NSABP B-43: A Phase III Clinical Trial Comparing Trastuzumab Given Concurrently with Radiation Therapy and Radiation Therapy Alone for Women with HER2-Positive Ductal Carcinoma In Situ Resected by Lumpectomy

Physician Summary: ≥ age 18, Central HER2 Testing: RT +/- Trastuzumab

(St. Mary's & MMC Only)  B-39: A Randomized Phase III Study of Conventional Whole Breast Irradiation (WBI) Versus Partial Breast Irradiation (PBI) for Women with Stage 0, I, or II Breast Cancer

Physician Summary: <age 50 if stage 0; >age 50 for Stage I & II if Node+ and/or ER-/PR-: Conventional Whole Breast Irradiation (WBI) vs. Partial Breast Irradiation (PBI)

NSABP B-43: A Phase III Clinical Trial Comparing Trastuzumab Given Concurrently with Radiation Therapy and Radiation Therapy Alone for Women with HER2-Positive Ductal Carcinoma In Situ Resected by Lumpectomy

Physician Summary: ≥ age 18, Central HER2 Testing: RT +/- Trastuzumab

Closing 8/16/10!  R-04: A Clinical Trial Comparing Preoperative Radiation Therapy and Capecitabine with or without Oxaliplatin with Preoperative Radiation Therapy and Continuous Intravenous Infusion of 5-Flourouracil with or without Oxaliplatin in t

Physician Summary: Neoadjuvant; Stage II/III; complete colonoscopic exam required: CI 5FU + XRT +/- Oxaliplatin vs Capecitabine + XRT +/- Oxaliplatin

(Saint Mary's Health Care Only)  RTOG 0813 - Seamless Phase I/II Study of Stereotactic Lung Radiotherapy (SBRT) for Early Stage, Centrally Located Non-Small Cell Lung Cancer (NSCLC) in Medically Inoperable Patients 

Physician Summary: > Age 18; NSCLC Stage T1-2, N0, M0; Treatment: SBRT (Stereotactic Lung Radiotherapy)

(St. Mary's Only)  0617: A Randomized Phase IIII Comparison Of Standard- Dose (60 Gy) Versus High-Dose (74 Gy) Conformal Radiotherapy With Concurrent And Consolidation Carboplatin/Paclitaxel +/- Cetuximab (IND #103444) I

Physician Summary: ≥ age 18, Newly Dx, unresectable Stage IIIA/IIIB: Standard vs High-dose conformal RT with Concurrent and Consolidation Carboplatin/Paclitaxel

ARST0332: Risk-Based Treatment for Pediatric Non-Rhabdomyosarcoma Soft Tissue Sarcomas (NRSTS)

Physician Summary: < age 30, Surgery vs Surgery + XRT vs Surgery + Chemo + XRT/Surgery vs Chemo + XRT + Surgery + Chemo + XRT/Surgery (Chemo = Ifosfomide + Doxirubicin)